Prof. Xunwei Wu (MD PhD)

Professor, Principal Investigator, School of Stomatology, Shandog University, Jinan, China

 

 

ABOUT

Xunwei Wu received his MD from Zhejiang Medical University, Hangzhou in 1993, and his PhD from Fudan University, Shanghai, in 2001. He did his post-doctoral training in Max Planck Institute of Biochemistry, Germany and then in Harvard Medical School, Boston. In 2010, he became a senior scientist in Adreans Research Institute, Atlanta, and in 2013 he moved back to Harvard Medical School as an instructor position. In 2015, he accepted a principal investigator position in Shandong University, Jinan, China.

RESEARCH INTERESTS

Dr. Wu’s research interest is to understand the function of dermal fibroblasts in maintaining skin homeostasis. His current research is mainly focused on two areas:

(1) The role of dermal fibroblast in regulating the development of melanoma;

(2) The role dermal fibroblast in controlling wound healing and skin regeneration.

 

RELEVANT PUBLICATIONS

  1. Czuchra A, Wu X, Meyer H, van Hengel J, Schroeder T, Geffers R, Rottner K, Brakebusch C. Cdc42 is not essential for filopodia formation, directed migration, cell polarization and mitosis in fibroblastoid cells. Mol Biol Cell 2005, 16(10):4473-84
  2. Wu X, Quondamatteo F, Levefer T, Czuchra A, Meyer H, Chrostek A, et al. Cdc42 controls progenitor cell differentiation and b-catenin turnover in skin. Genes&Dev. 2006, 20(5): 571-585
  3. Wu X, Quondamatteo F and Brakebusch C. Cdc42 expression in keratinocytes is required for the maintenance of the basement membrane in skin. Martrix Biology, 2006, 25(8):466-474
  4. Cappello S, Attardo A, Wu X, Iwasato T, Itohara S, Wilsch-Brauninger M, et al. The Rho-GTPase Cdc42 regulates cortical progenitor fate at apical surfac. Nature Neroscience, 2006, 9(9):1099-1107
  5. Chrostek A, Wu X, Quondamatteo F, Hu R, Sanecka A, Niemann C, Langbein L, Haase I, Brakebusch C. Rac1 is crucial for the hair follicle integrity, but is not essential for the maintenance of epidermis. MCB, 2006, 26(18): 6957-6970
  6. Thurnherr T, Benninger Y, Wu X, Chrostek A, Krause SM, Nave KA, Franklin RJ, Brakebusch C, Suter U and Relvas JB. Cdc42 and rac1 signaling are both required for and act synergistically in the correct formation of myelin sheaths in the central nervous system . J Neurosci. 2006, 26(40):10110-10119
  7. Wu X, Li S, Chrostek-Grashoff A, Czuchra A, Meyer H, Yurchenco PD, Brakebusch C. Cdc42 is crucial for the establishment of epithelial polarity during early mammalian development. Dev Dyn. 2007 236(10):2767-78.
  8. Bosse T, Ehinger J, Czuchra A, Benesch S, Steffen A, Wu X, Schloen K, Niemann HH, Scita G, Stradal TE, Brakebusch C, Rottner K. Cdc42 and phosphoinositide 3-kinase drive Rac-mediated actin polymerization downstream of c-Met in distinct and common pathways. MCB. 2007 27(19): 6615-28.
  9. Garvalov BK, Flynn KC, Neukirchen D, Meyn L, Teusch N, Wu X, Brakebusch C, Bamburg JR, Bradke F. Cdc42 regulates cofilin during the establishment of neuronal polarity. J Neurosci. 2007, 27(48):13117-29
  10. Benninger Y, Thurnherr T, Pereira JA, Krause S, Wu X, Chrostek-Grashoff A, Herzog D, Nave KA, Franklin RJM, Meijer D, Brakebusch C, Suter U, and Relvas JB. Essential and distinct roles for cdc42 and rac1 in the regulation of Schwann cell biology during peripheral nervous system development. JCB, 2007, 177(6): 1051-61
  11. van Hengel J, Dhooge P, Hooghe B, Wu X, Libbrecht L, De Vos R, et al. Continuous cell injury promotes hepatic tumorigenesis in Cdc42-deficient mouse liver. Gastroenterology, 2008, 134(3): 781-92
  12. Wu X, Liang Y, Jin T, Ye T, Kong Q, Wang Z, Lei L, Bergdahl IA, Nordberg GF. Renal effects evolution in a Chinese population after reduction of cadmium exposure in rice. Environ Res. 2008, 108(2):233-8
  13. Yuan H, Zhang H, Wu X, Zhang Z, Du D, Zhou W, Zhou S, Brakebusch C, and Chen Z. Hepatocyte-specific deletion of Cdc42 results in delayed liver regeneration after partial hepatectomy in mice. Hepatology 2008, 49(1):240-9
  14. Du D, Pedersen E, Wang Z, Karlsson R, Chen Z, Wu X, Brakebusch C. Cdc42 is crucial for the maturation of primordial cell junctions in keratinocytes independent of Rac1.Exp Cell Res. 2009, 315(8):1480-9
  15. Lammermann T, Renkawitz J, Wu X, Hirsch K, Brakebusch C, Sixt M. Cdc42-dependent leading edge coordination is essential for interstitial dendritic cell migration. Blood 2009,113(23):5703-10
  16. Fuchs S, Herzog D, Sumara G, Büchmann-Møller S, Civenni G, Wu X, Chrostek-Grashoff A, Suter U, Ricci R, Relvas JB, Brakebusch C, Sommer L. Stage-specific control of neural crest stem cell proliferation by the small rho GTPases Cdc42 and Rac1. Cell Stem Cell. 2009, 4(3):236-47.
  17. Nordberg GF, Jin T, Wu X, Lu J, Chen L, Lei L, Hong F, Nordberg M. Prevalence of kidney dysfunction in humans – Relationship to cadmium dose, metallothionein, immunological and metabolic factors. Biochimie. 2009, 91(10): 1282-5
  18. Mandinova A, Kolev V, Neel V, Hu B, Stonely W, Lieb J, Wu X, Colli C, Han R, Pazin M, Ostano P, Dummer R, Brissette JL, Dotto GP. A positive FGFR3/FOXN1 feedback loop underlies benign skin keratosis versus squamous cell carcinoma formation in humans. J Clin Invest. 2009, 119(10):3127-37
  19. Kesavan G, Sand FW, Greiner TU, Johansson JK, Kobberup S, Wu X, Brakebusch C, Semb H. Cdc42-mediated tubulogenesis controls cell specification. Cell. 2009, 139(4):791-801.
  20. Lefever T, Pedersen E, Basse A, Paus R, Quondamatteo F, Stanley AC, Langbein L, Wu X, Wehland J, Lommel S, Brakebusch C. N-WASP is a novel regulator of hair-follicle cycling that controls antiproliferative TGF {beta} pathways. J Cell Sci. 2010, 123(Pt 1):128-140.
  21. Pleines I, Eckly A, Elvers M, Hagedorn I, Eliautou S, Bender M, Wu X, Lanza F, Gachet C, Brakebusch C, Nieswandt B. Multiple alterations of platelet functions dominated by increased secretion in mice lacking Cdc42 in platelets. Blood. 2010,115(16):3364-73
  22. Du D, Xu F, Yu L, Zhang C, Lu X, Yuan H, Huang Q, Zhang F, Bao H, Jia L, Wu X, Zhu X, Zhang X, Zhang Z, Chen Z. The Tight Junction Protein, Occludin, Regulates the Directional Migration of Epithelial Cells. Dev Cell. 2010, 18(1):52-63.
  23. Wu X, Nguyen BC, Dziunycz P, Chang S, Brooks Y, Lefort K, Hofbauer G and Dotto GP. Opposing roles for calcineurin and ATF3 in squamous skin cancer. Nature 2010, 465, 368-372
  24. Qi Y, Liu J, Wu X, Brakebusch C, Leitges M, Han Y, Corbett SA, Lowry SF, Graham AM, Li S. Cdc42 controls vascular network assembly through protein kinase Cι during embryonic vasculogenesis. Arterioscler Thromb Vasc Biol. 2011, 31 (8):1861-70.
  25. Nordberg G, Jin T, Wu X, Lu J, Chen L, Liang Y, Lei L, Hong F, Bergdahl IA, Nordberg M. Kidney dysfunction and cadmium exposure–factors influencing dose-response relationships. J Trace Elem Med Biol. 2012, 26(2-3):197-200
  26. Marshall BT, Ingraham CA, Wu X, Washenik K. Future horizons in hair restoration. Facial Plast Surg Clin North Am. 2013 Aug;21(3):521-8
  27. Dziunycz PJ, Lefort K, Wu X, Freiberger SN, Neu J, Djerbi N, Iotzowa-Weiss G, French LE, Dotto GP, Hofbauer GF. The Oncogene ATF3 is Potentiated by Cyclosporine A and Ultraviolet Light A. J Invest Dermatol. 2014, 134(7):1998-2004
  28. Wu X*, Scott L, Washenik K, Stenn K. Full-Thickness Skin with Mature Hair Follicles Generated from Tissue Culture-Expanded Human Cells. Tissue Engineering A, 2014 20(23-24):3314-21